Our Research
The role of mediators of DNA damage repair and DNA replication in GATA2 deficiency - investigating disease progression
Our team is using CRISPR F0 screens, in situ hybridization, live imaging of transgenic zebrafish and single cell genomics to study stem cell fitness and disease progression in our zebrafish model of GATA2 deficiency. The goal is to understand how disease progression occurs and how this can be mitigated or reversed. This research is paving the way for novel therapies and treatments for blood disorders. This work is funded by the CRUK.
Regulating blood stem cell emergence
We are investigating novel players in the TFGbeta and Notch signalling pathways that help shape the emergence of blood stem cells in the embryo.
We have several projects in this area, so get in touch if you're interested!
We want to shed new light on the underlying mechanisms of blood stem cell formation and identify better ways to generate stem cells in vitro for transplantation.
Epigenetic regulation of lineage fate by histone deacetylases
We are using chemical inhibitors, CRISPR technology, in situ hybridization, live imaging of transgenic zebrafish and single cell genomics to study how the haematopoietic and endothelial lineages are specified and maintained during development. A better understanding of this process will help improve the generation of blood stem cells in vitro for transplantation. This work is funded by the British Heart Foundation.
