Developmental Haematopoiesis and Disease Modelling Lab

Studying blood stem cells and haematopoietic disorders using zebrafish

Confocal image of a 2dpf trangenic embryo. blood stem cells in blue, vessels in white

Welcome

The Monteiro Lab are interested in the formation and differentiation of blood stem cells during embryonic development, and how mutations in key regulators of stem cell function affect these cells and their progeny in haematopoietic disorders. We use cutting-edge CRISPR-Cas9 technology, flow cytometry, genetics and single cell genomics in the zebrafish, mouse and human ES cells.

The Lab is based at the Department of Cancer and Genomic Sciences, Medical School, University of Birmingham, UK.

You can find a brief summary of some of our current projects here

Fully-funded MIBTP PhD project available

Research

Open positions

News

PhD opportunity: how does blood flow build blood stem cells?

(image generated with AI) We are looking for a motivated candidate for a fully funded 4-year BBSRC-funded PhD project as part of the Midlands Integrative Biosciences Training Partnership (#MIBTP). When the embryonic heart starts beating, the force of flowing blood does more than move cells around. It instructs the vessel wall to make blood stem cells, while telling neighbouring cells to sprout new vessels. How one mechanical cue produces two different fates from a single cell

Rui Monteiro

Zebrafish models unravel disease progression in GATA2 deficiency

The Monteiro group employed a zebrafish fish model to replicate what happens in patients who inherit the loss of one allele of the GATA2...

Rui Monteiro

2dpf cd41-gfpkdrl-dsred uninjected tiled scan6x1_2 magenta_cropped for website_edited.jpg

Open PhD position available!
Non-clinical PhD studentship (MIBTP doctoral programme) - blood flow as a regulator of stem cell identity

Open positions

Check out our projects and interests page